Classification of adolescent idiopathic scoliosis (AIS)

Adolescent idiopathic scoliosis (AIS): new gene, new variants

Introduction Many chromosomic locations have been linked with the AIS, however, no causative genes have been clearly identified. We recently identified two regions (3q12.1 and 5q13.3) containing possibly causative gene(S) of AIS (Edery et al. 2011). Our recent work identified diseasecausing variants in a gene (that we called PFK2) in French AIS families (Patten et al. submitted 2014). We sought...

Neurotransmitter patterns in patients with adolescent idiopathic scoliosis (AIS)

Results Review of the completed urinalyses revealed a trend towards elevated histamine, elevated norepinephrine and decreased serotonin in the AIS patients as compared to non-scoliotics. Since these neurotransmitters are typically expressed in specific cortical areas, this pattern of imbalance may manifest as a functional hemisphericity, causing asymmetrical efferent responses to peripheral, af...

Focus On Classification of adolescent idiopathic scoliosis

Scoliosis Research Society defined scoliosis deformity as a lateral curvature of the spine on a radiograph of the spine taken in standing position.1 The degree of the curve is measured as the angle between the most inclined vertebral end-plates at each end of the curve (the Cobb angle). There are many causes of scoliosis deformity. It can be structural due to spinal pathologies or non-structura...

Adolescent Idiopathic Scoliosis

Adolescent Idiopathic Scoliosis

BACKGROUND Scoliosis refers to deviation of spine greater than 10 degrees in the coronal plane. Idiopathic Scoliosis is the most common spinal deformity that develops in otherwise healthy children. The sub types of scoliosis are based on the age of the child at presentation. Adolescent idiopathic scoliosis (AIS) by definition occurs in children over the age of 10 years until skeletal maturity. ...